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ABE206 Anti-MLL2 (C-Term) Antibody

Detect MLL2 (C-Term) using this Anti-MLL2 antibody (C-Term) validated for use in western blotting & IHC.

Anti-MLL2 (C-Term) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: KMT2D, ALR, MLL2, MLL4 UniProt Number: O14686
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ABE206
100 µg  
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      Overview

      Replacement Information

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE206
      DescriptionAnti-MLL2 (C-Term) Antibody
      Alternate Names
      • Histone-lysine N-methyltransferase 2D
      • Lysine N-methyltransferase 2D
      • ALL1-related protein
      • Myeloid/lymphoid or mixed-lineage leukemia protein 2
      Background InformationMLL2, also known as Histone-lysine N-methyltransferase 2D, or Lysine N-methyltransferase 2D or ALL1-related protein, or Myeloid/lymphoid or mixed-lineage leukemia protein 2, and encoded by the gene KMT2D/ALR/MLL2/MLL4, is a histone methyltransferase that methylates Lys-4 of histone H3 to form H3K4me. H3K4me represents a specific tag for epigenetic transcriptional activation and for instance in estrogen receptor function where MLL2 acts as coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2 is also a component of the ASCOM/Mll2/3 complex which plays an important role during development particularly in lymphomagenesis. MLL2 is localized to the nucleus. MLL2 is expressed in most embryonic and adult tissues. Defects in MLL2 are associated with Kabuki syndrome, a congenital mental retardation syndrome with additional features, including postnatal dwarfism, facial and bone deformities. Defects are also associated with medulloblastoma a highly malignant primary brain tumor.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect MLL2 (C-Term) using this Anti-MLL2 antibody (C-Term) validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a representative lot detected MLL2 (C-term) in human breast cancer tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human MLL2 (C-term).
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KMT2D
      • ALR
      • MLL2
      • MLL4
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~75 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human testis tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected MLL2 (C-term) in 10 µg of human testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABE206 04053252944642

      Documentation

      Anti-MLL2 (C-Term) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MLL2 (C-Term) Antibody Certificates of Analysis

      TitleLot Number
      Anti-MLL2 (C-Term) - 3807978 3807978
      Anti-MLL2 (C-Term) - Q2361576 Q2361576
      Anti-MLL2 (C-Term) -2686110 2686110
      Anti-MLL2 (C-Term) -2806494 2806494
      Anti-MLL2 (C-Term) Polyclonal Antibody 3050674
      Anti-MLL2 (C-Term) Polyclonal Antibody 2909629

      References

      Reference overviewPub Med ID
      Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon.
      Natarajan, Thanemozhi G, et al.
      Cancer Cell Int., 10: 13 (2010)  2010

      Show Abstract       		20433758 20433758