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MABE1153-25UG Anti-MRE11 Antibody, clone 15B8.1E7.6

Anti-MRE11, clone 15B8.1E7.6 , Cat. No. MABE1153-25UG, is a highly specific armenian hamster monoclonal antibody, that targets Double-strand break repair protein MRE11A and has been tested in Western Blotting.

Anti-MRE11 Antibody, clone 15B8.1E7.6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: Mre11a, Mre11 UniProt Number: Q61216
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MABE1153-25UG
25 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBAHmPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE1153-25UG
      DescriptionAnti-MRE11 Antibody, clone 15B8.1E7.6
      Alternate Names
      • Double-strand break repair protein MRE11A
      • MmMRE11A
      • Meiotic recombination 11 homolog 1
      • MRE11 homolog 1
      • Meiotic recombination 11 homolog A
      • MRE11 homolog A
      Background InformationDouble-strand break repair protein MRE11A (UniProt: Q61216; also known as MmMRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A) is encoded by the Mrer11a (also known as Mre11) gene (Gene ID: 17535) in murine species. MRE11A a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. It localizes to discrete nuclear foci after treatment with genotoxic agents. MRE11A is a component of the MRN complex that possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11A forms a complex with the RAD50 homolog, which is required for non-homologous joining of DNA end. RAD50 may be required to bind DNA ends and hold them in close proximity, which facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. In conjunction with a DNA ligase, MRE11A is reported to promote the joining of non-complementary ends in vitro using short homologies near the ends of the DNA fragments.
      References
      Product Information
      FormatPurified
      PresentationPurified armenian hamster monoclonal antibodyIgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-MRE11, clone 15B8.1E7.6 , Cat. No. MABE1153-25UG, is a highly specific armenian hamster monoclonal antibody, that targets Double-strand break repair protein MRE11A and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected MRE11 in 10 µg of mouse embryo fibroblast cell lysate (MEFs).
      Biological Information
      ImmunogenRecombinant fragment corresponding to 540 amino acids from murine Double-strand break repair protein MRE11A.
      ConcentrationPlease refer to lot specific datasheet.
      HostArmenian Hamster
      SpecificityClone 15B8.1E7.6 detects Double-strand break repair protein MRE11A in human and murine cells.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Mre11a
      • Mre11
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight80 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Ramo cell lysate.
      Western Blotting Analysis: 4 µg/mL of this antibody detected MRE11 in 10 µg of Ramo cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABE1153-25UG 04054839447969