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MABF956 Anti-Mouse CD36 Antibody, Clone 63

Detect CD36 by using this mouse monoclonal Anti-Mouse CD36 Antibody, Clone 63, Cat. No. MABF956. It is used in Flow Cytometry and Inhibition studies.

Anti-Mouse CD36 Antibody, Clone 63 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: cd36 UniProt Number: Q08857
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MABF956
200 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, MFC, InhibitionMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF956
      DescriptionAnti-Mouse CD36 Antibody, Clone 63
      Alternate Names
      • Glycoprotein IIIb
      • GPIIIB
      • PAS IV
      • PAS-4
      • Platelet glycoprotein IV
      • GPIV
      • CD antigen CD36
      Background InformationPlatelet glycoprotein 4 (UniProt: Q08857; also known as Glycoprotein IIIb, GPIIIB, PAS IV, PAS-4, Platelet glycoprotein IV, GPIV, CD antigen: CD36) is encoded by the cd36 gene (Gene ID: 12491) in murine species. CD36 is a multifunctional glycoprotein that acts as receptor for a broad range of ligands, including oxLDL. CD36 is shown to play a role in scavenging oxLDL may also mediate effects of oxLDL on monocytes and platelets in atherosclerotic lesions. Upon ligand-binding, it is internalized through dynamin-dependent endocytosis. CD36 is highly expressed in the intestine on the luminal surface of enterocytes. In small intestines expression levels follow a steep decreasing gradient from proximal to distal segments. It is expressed in a circadian manner in the circumvallate papillae with its levels being lower during the dark period. In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation.CD36 null mice exhibit impaired chylomicron secretion, but no overall lipid absorption defect. CD36 can binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption. In taste receptor cells, CD36 is shown to mediate the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract. CD36 is also expressed in lung alveolar macrophages and dendritic macrophages. (Ref.: Nassir, F., et al. (2007). J. Biol. Chem. 282(27):19493-194501).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgA in PBS without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationDetect CD36 by using this mouse monoclonal Anti-Mouse CD36 Antibody, Clone 63, Cat. No. MABF956. It is used in Flow Cytometry and Inhibition studies.
      Key Applications
      • Flow Cytometry
      • Inhibition
      Application NotesFlow Cytometry Analysis: A representative lot detected Mouse CD36 in Flow Cytometry applications (Corcoran, L., et. al. (2002). Int Immunol. 14(10):1099-104).

      Inhibition Analysis: A representative lot detected Mouse CD36 in Inhibition applications (Patel, S.N., et. al. (2004). J Infect Dis. 189(2):204-13).
      Biological Information
      ImmunogenFull-length adenovirus vector injected into CD36 null mice.
      Epitopeextracellular domain
      Clone63
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 63 specifically detects CD36 in RAW264.7 cells.
      IsotypeIgAκ
      Species Reactivity
      • Rat
      • Mouse
      Species Reactivity NoteMouse, Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • cd36
      Purification MethodProtein L
      UniProt Number
      Molecular Weight52.70 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in RAW264.7 cells.

      Flow Cytometry Analysis: 1 µg of this antibody detected CD36 in one million RAW264.7 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.

      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABF956 04054839167461