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ABN98 Anti-Neurexin-1-alpha Antibody

Detect Neurexin-1-alpha using this Anti-Neurexin-1-alpha Antibody validated for use in WB, IH(P).

Anti-Neurexin-1-alpha Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Adhesion (CAMs) Gene Symbol: NRXN1 UniProt Number: Q9ULB1
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ABN98
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Chp, Rhesus Macaque, Ca, BWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN98
      DescriptionAnti-Neurexin-1-alpha Antibody
      Alternate Names
      • Neurexin-1-alpha
      • Neurexin I-alpha
      • Neurexin1
      Background InformationNeurexins are heavily glycosylated and processed neuronal transmembrane cell surface proteins likely involved in cell recognition and adhesion (see review by Missler & Sudhof, 1998). Antibody Anti-Neurexin-1-alpha (ABN35) was made against a peptide immunogen corresponding to a stretch of amino acids in the extracellular domain of human Neurexin-1-alpha (Uniprot Q9ULB1). Although the theoretical full length of Neurexin-1-alpha is 161 kDa, the protein detected in human brain lysates may show a band around 160 kDa and additional bands around 45 kDa as a possible result of the posttranslational processing previously reported.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human cerebellum tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Neurexin-1-alpha using this Anti-Neurexin-1-alpha Antibody validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Neurexin-1-alpha in human brain tissue.
      Biological Information
      ImmunogenKLH-conjugated Linear peptide corresponding to human Neurexin-1-alpha at the extracellular laminin G-like 3 domain.
      EpitopeExtracellular laminin G-like 3 domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Neurexin-1-alpha at the extracellular laminin G-like 3 domain.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Chimpanzee
      • Rhesus Macaque
      • Canine
      • Bovine
      Species Reactivity NoteDemonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee, Rhesus Macaque, Canine, and Bovine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNeurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq].
      Gene Symbol
      • NRXN1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

      SUBUNIT STRUCTURE: The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. The laminin G-like domain 2 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latroxin. Interacts with SYT13 and SYTL1 (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.

      TISSUE SPECIFICITY: Heart and brain.

      PTM: N- and O-glycosylated (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the neurexin family.

      Contains 3 EGF-like domains.

      Contains 6 laminin G-like domains.

      SEQUENCE CAUTION: The sequence BAA25504.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
      Molecular Weight~ 45 kDa Observed At higher concentrations or longer exposures, in certain lysates, a band at ~150kD can be seen that corresponds to the expected full length Mw.
      UniProtKB/Swiss-Prot Q9ULB1 (NRX1A_HUMAN) entry describes 3 isoforms produced by alternative promoter usage and alternative splicing. Reference (Accolade/Related Documents) TIG JANUARY 1998 VOL. 14 No. 1 indicates that multiple neurexin isoforms are generated from three genes by alternative promoters and alternative splicing.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human cerebellum tissue lysate.

      Western Blot Analysis: 0.1 µg/mL of this antibody detected Neurexin-1-alpha on 10 µg of human cerebellum tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABN98 04053252754845

      Documentation

      Anti-Neurexin-1-alpha Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Neurexin-1-alpha Antibody Certificates of Analysis

      TitleLot Number
      Anti-Neurexin-1-alpha - 2430651 2430651
      Anti-Neurexin-1-alpha - 2205024 2205024
      Anti-Neurexin-1-alpha - 3215526 3215526
      Anti-Neurexin-1-alpha - 3296145 3296145
      Anti-Neurexin-1-alpha - 3464586 3464586
      Anti-Neurexin-1-alpha - 3668244 3668244
      Anti-Neurexin-1-alpha - 3849584 3849584
      Anti-Neurexin-1-alpha - NRG1915887 NRG1915887
      Anti-Neurexin-1-alpha -2698487 2698487
      Anti-Neurexin-1-alpha Polyclonal Antibody 3123696
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