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AB5581-200UL Anti-P2X7 Receptor Antibody, extracellular domain

Anti-P2X7 Receptor Antibody, extracellular domain is an antibody against P2X7 Receptor for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: P2RX7, MGC20089, P2X7 UniProt Number: Q99572
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AB5581-200UL
200 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5581-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-P2X7 Receptor Antibody, extracellular domain
      References
      Product Information
      FormatAffinity Purified
      Control
      • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.05% sodium azide. Reconstitute with 200 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-P2X7 Receptor Antibody, extracellular domain is an antibody against P2X7 Receptor for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blotting: 1:200 using ECL on rat brain membranes.

      Flow cytometry, indirect: 5-10 μg antibody per 1x10E6 cells.

      Dilutions should be made using a carrier protein such as BSA (1-3%).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHighly purified peptide corresponding to residues 136-152 of mouse P2X7 (Accession Q9Z1M0).
      Epitopeextracellular domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes P2X7, extracellular domain.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.
      Gene Symbol
      • P2RX7
      • MGC20089
      • P2X7
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q99572 # Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
      SIZE: 595 amino acids; 68559 Da
      SUBUNIT: Forms homo- or heteropolymers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      PTM: Phosphorylation results in its inactivation.
      SIMILARITY: SwissProt: Q99572 ## Belongs to the P2X receptor family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 6 months after date of receipt. After reconstitution maintain antibody and control peptide at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      AB5581-200UL 04053252283000

      Documentation

      Anti-P2X7 Receptor Antibody, extracellular domain SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-P2X7 Receptor Antibody, extracellular domain Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2459027 2459027
      RABBIT ANTI-P2X7 -2716598 2716598
      RABBIT ANTI-P2X7 -2736649 2736649
      RABBIT ANTI-P2X7 -2776254 2776254
      RABBIT ANTI-P2X7 -2788896 2788896
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3136395
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3010003
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2033633 2033633
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2179301 2179301
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2327685 2327685

      Data Sheet

      Title
      RABBIT ANTI-P2X7 AFFINITY PURIFIED POLYCLONAL ANTIBODY