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AB5178-50UL Anti-Potassium Channel Kv1.3 Antibody

Anti-Potassium Channel Kv1.3 Antibody detects level of Potassium Channel Kv1.3 & has been published & validated for use in IH & WB.

Anti-Potassium Channel Kv1.3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: KCNA3, HLK3, HGK5, KV1.3, HuKIII, HPCN3, Kv1.3, MK3, HUKIII, PCN3 UniProt Number: P22001
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AB5178-50UL
50 µL  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIHC, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5178-50UL
      ReplacesAB9784
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Potassium Channel Kv1.3 Antibody
      References
      Product Information
      FormatPurified
      Control
      • Included free of charge with the antibody is 120 µg of control antigen. The stock solution of the antigen can be made up using 100 μL of PBS. For positive control, in Western blot using 20 ng of protein per minigel lane. For negative control, preincubate 3 μg of fusion protein with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, 5% sucrose as a stabilizer and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-Potassium Channel Kv1.3 Antibody detects level of Potassium Channel Kv1.3 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry on rat brain sections.

      Western blot: 1:200 using ECL on rat brain membranes.

      Dilutions should be made using a carrier protein such as BSA (1-3%)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGST fusion protein and a C-terminal portion of human Kv1.3 protein (amino acids 471-523) (Accession P22001).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes a full length Kv1.3 protein. Does not cross react with any other potassium channel antigens tested so far.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPotassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
      Gene Symbol
      • KCNA3
      • HLK3
      • HGK5
      • KV1.3
      • HuKIII
      • HPCN3
      • Kv1.3
      • MK3
      • HUKIII
      • PCN3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22001 # Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
      SIZE: 523 amino acids; 58304 Da
      SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DOMAIN: SwissProt: P22001 The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. & The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
      SIMILARITY: Belongs to the potassium channel family. A (Shaker) subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      AB5178-50UL 04053252470035

      Documentation

      Anti-Potassium Channel Kv1.3 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Potassium Channel Kv1.3 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) PURIFIED POLYCLONAL ANTIBODY - 2391406 2391406
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) - 4030981 4030981
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) -2494609 2494609
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) PURIFIED POLYCLONAL ANTIBODY 2981175
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) PURIFIED POLYCLONAL ANTIBODY 3056335
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) PURIFIED POLYCLONAL ANTIBODY - 3927161 3927161
      RABBIT ANTI-Kv1.3 -2824793 2824793
      RABBIT ANTI-Kv1.3 -2846396 2846396

      Data Sheet

      Title
      RABBIT ANTI-Kv1.3 (Charybdotoxin-sensitive voltage-dependent potassium channel, HLK3) PURIFIED POLYCLONAL ANTIBODY

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      Alternative Packsize

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies