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07-1463 Anti-Rho (-A, -B, -C) Antibody

Detect Rho (-A, -B, -C) using this Anti-Rho (-A, -B, -C) Antibody validated for use in WB.

Anti-Rho (-A, -B, -C) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: G-proteins Gene Symbol: ARHS , FLJ42294, RHO6, RHOS, Rho6, Rnd1 UniProt Number: Q92730
07-1463
100 µg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1463
      DescriptionAnti-Rho (-A, -B, -C) Antibody
      Alternate Names
      • GTP-binding protein
      • GTP-binding protein RHO6
      • Rho family GTPase 1
      • ras homolog gene family, member S
      Background InformationRho proteins belong to the Ras super family of low molecular weight GTPases, which includes RAS, RHO, RAB, RAN, RAD and ARF. These small GTP binding proteins function as molecular switches that regulate a multitude of biological processes including cell proliferation, apoptosis, differentiation, cytoskeletal reorganization, and membrane trafficking.
      References
      Product Information
      FormatPurified
      Control
      • HL-60 cell lysate
      PresentationPurified immunoglobulin in buffer containing 0.02 M phosphate buffer with 0.15 M NaCl, pH 7.6 and 0.1% sodium azide.
      Applications
      ApplicationDetect Rho (-A, -B, -C) using this Anti-Rho (-A, -B, -C) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to human Rho.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Rho-A, -B, -C. This antibody detects an ~22 kDa band, corresponding to the expected molecular weight of Rho.
      Species Reactivity
      • Human
      Species Reactivity NoteProven to react with human.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARHS
      • FLJ42294
      • RHO6
      • RHOS
      • Rho6
      • Rnd1
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION:Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
      SUBUNIT STRUCTURE: Binds GRB7 and PLXNB1. Interacts with UBXD5.
      SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm › cytoskeleton Ref.9.
      TISSUE SPECIFICITY: Mostly expressed in brain and liver.
      SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Rho family.
      Molecular Weight20 to 22 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HL-60 cell lysate.
      Western Blot Analysis: 0.5 µg/mL of this antibody detected Rho on 10 µg of HL-60 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      07-1463 04053252339158