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MABC786 Anti-TSG101, clone 4A10 Antibody

Anti-TSG101, clone 4A10 Antibody is an antibody against TSG101, clone 4A10 for use in Western Blotting, Immunohistochemistry, ELISA.

Anti-TSG101, clone 4A10 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TSG101 UniProt Number: Q99816
MABC786
100 μg  
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      Overview

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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHC, ELISAMAffinity PurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC786
      DescriptionAnti-TSG101, clone 4A10 Antibody
      Alternate Names
      • Tumor susceptibility gene 101 protein
      • TSG101
      • ESCRT-I complex subunit TSG101
      Background InformationTumor susceptibility gene 101 protein (TSG101), also known as ESCRT-I complex subunit TSG101, refers to a series of cytosolic protein complexes that are needed for the proper recognition and sorting of ubiquitin modified carrier proteins into the internal vesicles of the things like endosomes, and other multivesicular bodies (MVBs). TSG101 binds to the ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into MVBs. TSG101 also mediates the association between the ESCRT-0 and ESCRT-I complex in the passage of ubiquitin cargo proteins along the chain of ESCRTs. TSG101 interacts with a protein called stathmin, a cytoplasmic phosphoprotein that is implicated in tumorigenesis, and normal TSG101 appears to act as a negative regulator of growth, genetic stability and cell cycle regulation. Mutations and alternatively spliced mutants are associated with breast and other cancers suggesting that defects in TSG101 assist in tumorigenesis and progression.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified mouse monoclonal containing PBS, pH 7.4.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TSG101, clone 4A10 Antibody is an antibody against TSG101, clone 4A10 for use in Western Blotting, Immunohistochemistry, ELISA.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • ELISA
      Application NotesImmunohistochemistry Analysis (IHP): A 1:100 dilution from a representative lot detected TSG101 in colon carcinoma tissue.

      ELISA: The specificity of a representative lot was confirmed by ELISA analysis.
      Biological Information
      ImmunogenTSG101 protein expressed in E. coli.
      Clone4A10
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse, (H, M)
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • TSG101
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~48 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa, NIH/3T3, JC, C2C12 , HEK293, A431 and BCL-1 cell lysates.

      Western Blotting Analysis (WB): A 1:500-1,000 dilution of this antibody detected TSG101 in HeLa, NIH/3T3, JC, C2C12 , HEK293, A431 and BCL-1 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MABC786 04055977350296