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AB9834 Anti-Tyrosine Kinase Receptor C Antibody

Tyrosine Kinase Receptor C is an antibody targeting the Tyrosine Kinase Receptor C protein, validated for use in IHC.

Anti-Tyrosine Kinase Receptor C Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins Gene Symbol: NTRK3, TRKC, gp145(trkC), Trk-C, GP145-TrkC, EC 2.7.10.1 UniProt Number: Q16288
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AB9834
50 µL  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB9834
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tyrosine Kinase Receptor C Antibody
      Alternate Names
      • trkC
      Background InformationThe mammalian Trk family of receptor tyrosine kinases consists of three principle transmembrane proteins. The receptors can be activated by one or more of four neurotrophins - NGF, BDNF, NT3 and NT4. Each of the four members of the TrkC family, expressed by alternative splicing, serves as a receptor for NT-3, with some evidence for endogenous activation also by NGF. These neurotrophins regulate biological responses such as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells primarily, but several other cell types have been shown to express the TrkC receptor. The receptor has also been demonstrated on many tumors of neuronal origin.
      References
      Product Information
      FormatSerum
      PresentationLyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationTyrosine Kinase Receptor C is an antibody targeting the Tyrosine Kinase Receptor C protein, validated for use in IHC.
      Key Applications
      • Immunohistochemistry
      Application NotesResults of immunohistochemistry in the dorsal root ganglion have been described by Chen. C., et al., Neurochemical Research (1996) 21(7):809-814..
      Biological Information
      ImmunogenExtracellular domain of the recombinant human receptor expressed in mammalian cells.
      HostRabbit
      SpecificitytrkC [Neurotrophin-3 growth factor receptor; tyrosine kinase receptor C]. All four forms of the TrkC receptor are expected to be detected by this antibody. The immunogen sequence was chosen to avoid cross reactivity with trkA or trkB.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
      Gene Symbol
      • NTRK3
      • TRKC
      • gp145(trkC)
      • Trk-C
      • GP145-TrkC
      • EC 2.7.10.1
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
      SIZE: 839 amino acids; 94428 Da
      SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
      PTM: Ligand-mediated auto-phosphorylation.
      SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      AB9834 04053252743009

      Documentation

      Anti-Tyrosine Kinase Receptor C Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tyrosine Kinase Receptor C Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-trkC (Tyrosine Kinase Receptor C) - 4208504 4208504
      RABBIT ANTI-trkC (Tyrosine Kinase Receptor C) POLYCLONAL ANTIBODY - 2009002 2009002
      RABBIT ANTI-trkC (Tyrosine Kinase Receptor C) POLYCLONAL ANTIBODY - 2224422 2224422
      RABBIT ANTI-trkC (Tyrosine Kinase Receptor C) POLYCLONAL ANTIBODY - 2275564 2275564
      RABBIT ANTI-trkC (Tyrosine Kinase Receptor C) POLYCLONAL ANTIBODY - 2320059 2320059
      RABBIT ANTI-trkC - 3587183 3587183
      RABBIT ANTI-trkC - 3784148 3784148
      RABBIT ANTI-trkC -2747997 2747997

      References

      Reference overviewPub Med ID
      Involvement of neurotrophin-3 (NT-3) in the functional elimination of synaptic contacts during neuromuscular development.
      Neus Garcia,Manel M Santafé,Marta Tomàs,Maria A Lanuza,Nuria Besalduch,Josep Tomàs
      Neuroscience letters  473  2010

      Show Abstract       		20178830 20178830

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies