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196419 BAPTA/AM - CAS 126150-97-8 - Calbiochem

BAPTA/AM - CAS 126150-97-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester

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196419
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
126150-97-8C₃₄H₄₀N₂O₁₈

Pricing & Availability

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196419-25MG
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      		 Plastic ampoule 25 mg
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      Description
      OverviewMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Abolishes vitamin D3-induced increase in intracellular Ca2+. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
      Catalogue Number196419
      Brand Family Calbiochem®
      Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
      References
      ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
      Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
      Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
      Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
      Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
      Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
      Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
      Tsien, R.Y. 1981. Nature 290, 527.
      Tsien, R.Y. 1980. Biochemistry 19, 2396.
      Product Information
      CAS number126150-97-8
      FormLight yellow solid
      Hill FormulaC₃₄H₄₀N₂O₁₈
      Chemical formulaC₃₄H₄₀N₂O₁₈
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      196419-25MG 04055977206494

      Documentation

      BAPTA/AM - CAS 126150-97-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BAPTA/AM - CAS 126150-97-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      196419

      References

      Reference overview
      Bissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
      Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
      Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
      Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
      Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
      Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
      Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
      Tsien, R.Y. 1981. Nature 290, 527.
      Tsien, R.Y. 1980. Biochemistry 19, 2396.

      Citations

      Title
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      Synonyms1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid Tetra(acetoxymethyl) Ester
      DescriptionMembrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number126150-97-8
      Chemical formulaC₃₄H₄₀N₂O₁₈
      Structure formulaStructure formula
      Purity≥90% by TLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesBissonnette, M., et al. 1994. Am. J. Physiol. 267, G465.
      Jiang, S., et al. 1994. Exp. Cell Res. 212, 84.
      Billman, G.E. 1993. Am. J. Physiol. 265, H1529.
      Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171.
      Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133.
      Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A.
      Marban, E., et al. 1986. J. Clin. Invest. 78, 1185.
      Tsien, R.Y. 1981. Nature 290, 527.
      Tsien, R.Y. 1980. Biochemistry 19, 2396.
      Citation
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
      		•

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