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SCT210-175nmol BioTracker FerroOrange Live Cell Dye

Live Cell imaging probe that specifically detects labile ferrous (Fe2+) ions in live cells.

SCT210-175nmol
5 x 35 nmol  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT210-175nmol
      DescriptionBioTracker FerroOrange Live Cell Dye
      OverviewIron, the most abundant transition metal in our bodies, is involved in a number of biologically important processes such as respiration, oxygen transport, and energy production in collaboration with oxygen. In living cells, iron exists mainly as ferrous (Fe2+) and ferric (Fe3+) ionic forms. As a major contributor to oxidative damage of cells, Fe2+ is implicated in serious diseases such as cancers and neurodegenerative disorders, because of its ability to produce harmful reactive oxygen species via contact with oxygen, superoxide, and hydrogen peroxide (H2O2).

      BioTracker FerroOrange Live Cell Dye is an orange fluorescent probe that specifically detects labile iron (II) ions (Fe2+) only. The intensity of fluorescence does not increase in the presence of iron (III) ions (Fe3+) or bivalent metal ions other than iron. It also does not react to chelated iron in ferritin and other substances. FerroOrange is suitable for live-cell imaging because it is highly cell-permeable and has low cell toxicity.

      Spectral Properties
      Absorbance (max): 542 nm
      Emission (max): 572 nm

      References
      Tomita K et al. MiR-7-5p is a key factor that controls radioresistance via intracellular Fe2+ content in a clinically relevant radioresistant cells. Biochem. and Biophy. Res. Commun. 2019. Oct; 518(4): 712-718.
      Alternate Names
      • FerroOrange, 35 nmol×5
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive Cell imaging probe that specifically detects labile ferrous (Fe2+) ions in live cells.
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging. Orange fluorescence.
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 95% (LC)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker FerroOrange Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size5 x 35 nmol
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      SCT210-175nmol 0