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219477 Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem

The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,4-Dimethoxyacridine-9(10H)-thione

Primary Target: CDK4/D1
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219477
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
141992-47-4C₁₅H₁₃NO₂S

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219477-5MG
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      Description
      OverviewA thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 > 100 µM).
      Catalogue Number219477
      Brand Family Calbiochem®
      Synonyms1,4-Dimethoxyacridine-9(10H)-thione
      References
      ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
      Product Information
      CAS number141992-47-4
      ATP CompetitiveN
      FormBrown solid
      Hill FormulaC₁₅H₁₃NO₂S
      Chemical formulaC₁₅H₁₃NO₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCDK4/D1
      Primary Target IC<sub>50</sub>200 nM against CDK4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      219477-5MG 04055977218541

      Documentation

      Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      219477

      References

      Reference overview
      Kubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-December-2009 RFH
      Synonyms1,4-Dimethoxyacridine-9(10H)-thione
      DescriptionA potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 >100 µM).
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number141992-47-4
      Chemical formulaC₁₅H₁₃NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (2.5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.