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HTS013M ChemiSCREEN™ CCR8 Membrane Preparation

Human CCR8 GPCR membrane prepation for Radioligand binding Assays.

Host Cell: Chem-1 Uni Prot Number: P51685 Entrez Gene Number: NM_005201.2
HTS013M
200 assays  
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      Overview

      Replacement Information

      Key Specifications Table

      SpeciesHost CellsProtein Target
      Human Chem-1CCR8
      Description
      Catalogue NumberHTS013M
      Brand Family Chemicon®
      Trade Name
      • ChemiScreen
      • Chemicon
      DescriptionChemiSCREEN™ CCR8 Membrane Preparation
      References
      Product Information
      FormatMembranes
      PresentationLiquid in packaging buffer: 50 mM Tris pH 7.4, 10% glycerol and 1% BSA with no preservatives.
      Packaging method: Membrane protein was adjusted to 1 mg/ml in packaging buffer, rapidly frozen, and stored at -80°C.
      Quality LevelMQ100
      Applications
      ApplicationHuman CCR8 GPCR membrane prepation for Radioligand binding Assays.
      Key Applications
      • Radioligand binding assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
      Gene Symbol
      • CCR8
      • CMKBR8
      • MGC129973
      • GPRCY6
      • TER1
      • CKR-L1
      • CCR-8
      • MGC129966
      • CC-CKR-8
      • CY6
      • CKRL1
      • CDw198
      • CMKBRL2
      • GPR-CY6
      GPCR ClassA
      Host CellsChem-1
      Protein TargetCCR8
      Target Sub-FamilyChemokine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51685 # Receptor for the chemokine SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
      SIZE: 355 amino acids; 40844 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: P51685 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size200 assays
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      HTS013M 04053252627194

      Documentation

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      Categories

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      Life Science Research > Proteins and Enzymes > GPCR Membrane Preparations