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204878 Complement C1r, Human, Activated, Two-Chain Form

Complement C1r, Human, Activated, Two-Chain Form, CAS 80295-34-7, is a native, activated, C1r complement component.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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204878
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Overview

Replacement Information

Pricing & Availability

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204878-250UG
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      		 Plastic ampoule 250 μg
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      Description
      OverviewNative, human, activated, C1r complement component. Generally the non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35 kDa peptide contains C1r enzymatic active site. Activated C1r continues activation via classical pathway by cleaving, and thus activating C1s.
      Catalogue Number204878
      Brand Family Calbiochem®
      References
      ReferencesVilliers, C.L., et al. 1983. Biochem. J. 215, 369.
      Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.
      Product Information
      CAS number80295-34-7
      FormLiquid
      FormulationIn 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activity≥80% of C1r will bind with excess C1-INH
      Purity≥90% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsIgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      204878-250UG 04055977219715

      Documentation

      Complement C1r, Human, Activated, Two-Chain Form SDS

      Title

      Safety Data Sheet (SDS) 

      Complement C1r, Human, Activated, Two-Chain Form Certificates of Analysis

      TitleLot Number
      204878

      References

      Reference overview
      Villiers, C.L., et al. 1983. Biochem. J. 215, 369.
      Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-March-2024 JSW
      DescriptionNative, human, activated, C1r complement component. Generally, non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to the classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35,000 peptide contains C1r enzymatic active site. Activated C1r continues activation via the classical pathway by cleaving, and thus activating C1s.
      FormLiquid
      FormulationIn 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number80295-34-7
      Purity≥90% by SDS-PAGE
      ContaminantsIgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts
      Biological activity≥80% of C1r will bind with excess C1-INH
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesVilliers, C.L., et al. 1983. Biochem. J. 215, 369.
      Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.