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182015 Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem

Potent inhibitor of cell adhesion.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RGDFV Peptide, Cyclic

Primary Target: inhibits tumor cell adhesion to laminin and vitronectin substrates
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182015
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
137813-35-5C₂₆H₃₈N₈O₇

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      Description
      OverviewPotent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
      Catalogue Number182015
      Brand Family Calbiochem®
      SynonymsRGDFV Peptide, Cyclic
      References
      ReferencesShono, T., et al. 2001. Exp. Cell Res. 268, 169.
      Matsuno, H., et al. 1994. Circulation 90, 2203.
      Noiri, E., et al. 1994. Kidney Int. 46, 1050.
      Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
      Product Information
      CAS number137813-35-5
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt
      Hill FormulaC₂₆H₃₈N₈O₇
      Chemical formulaC₂₆H₃₈N₈O₇
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      182015-1MG 04055977205039

      Documentation

      Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      182015

      References

      Reference overview
      Shono, T., et al. 2001. Exp. Cell Res. 268, 169.
      Matsuno, H., et al. 1994. Circulation 90, 2203.
      Noiri, E., et al. 1994. Kidney Int. 46, 1050.
      Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2008 RFH
      SynonymsRGDFV Peptide, Cyclic
      DescriptionPotent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt
      CAS number137813-35-5
      Chemical formulaC₂₆H₃₈N₈O₇
      Purity≥95% by HPLC
      Solubility1 N Acetic acid (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesShono, T., et al. 2001. Exp. Cell Res. 268, 169.
      Matsuno, H., et al. 1994. Circulation 90, 2203.
      Noiri, E., et al. 1994. Kidney Int. 46, 1050.
      Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.