Millipore Sigma Vibrant Logo

567726 D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide

View Products on Sigmaaldrich.com
567726
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
123-78-4C₁₈H₃₇NO₂

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
567726-10MG
Retrieving availability...
—
Limited Availability Limited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 10 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      Description
      OverviewHighly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.
      Catalogue Number567726
      Brand Family Calbiochem®
      SynonymsCerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
      References
      Product Information
      CAS number123-78-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₃₇NO₂
      Chemical formulaC₁₈H₃₇NO₂
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>2.8 µM against PKC
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      567726-10MG 04055977190830

      Documentation

      D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      D-erythro-Sphingosine, Free Base, High Purity - CAS 123-78-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      567726

      Brochure

      Title
      Bioactive Lipids Technical Bulletin
      PKC Pathway Poster PDF ( 676 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsCerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
      DescriptionHighly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC50 = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca2+. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
      FormWhite solid
      CAS number123-78-4
      Chemical formulaC₁₈H₃₇NO₂
      Purity≥98% by TLC
      SolubilityMethanol (1 mg/ml), Chloroform (1 mg/ml), or DMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.
      Toxicity Irritant
      Merck USA index14, 8747