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342500 FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tacrolimus

Primary Target: Immunosuppressant that blocks T cell proliferation
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342500
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
104987-11-3C₄₄H₆₉NO₁₂

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      Description
      OverviewImmunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
      Catalogue Number342500
      Brand Family Calbiochem®
      SynonymsTacrolimus
      References
      ReferencesAsano, K., et al. 1996. In Vivo 10, 537.
      McCall, E., et al. 1996. Circ. Res. 79, 1110.
      Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
      Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
      Product Information
      CAS number104987-11-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₄₄H₆₉NO₁₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetImmunosuppressant that blocks T cell proliferation
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKD4200000
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      342500-5MG 04055977195002

      Documentation

      FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      342500

      References

      Reference overview
      Asano, K., et al. 1996. In Vivo 10, 537.
      McCall, E., et al. 1996. Circ. Res. 79, 1110.
      Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
      Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-April-2009 JSW
      SynonymsTacrolimus
      DescriptionImmunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
      FormOff-white solid
      CAS number104987-11-3
      RTECSKD4200000
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesAsano, K., et al. 1996. In Vivo 10, 537.
      McCall, E., et al. 1996. Circ. Res. 79, 1110.
      Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
      Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.