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345885 GGTI-2147 - CAS 191102-87-1 - Calbiochem

A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I).

GGTI-2147 - CAS 191102-87-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester

Primary Target: GGTase-I
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345885
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
191102-87-1C₂₈H₃₀N₄O₃

Pricing & Availability

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345885-250UG
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      		 Plastic ampoule 250 μg
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      Description
      OverviewA cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
      Catalogue Number345885
      Brand Family Calbiochem®
      Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
      References
      ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
      Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
      Product Information
      CAS number191102-87-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₈H₃₀N₄O₃
      Chemical formulaC₂₈H₃₀N₄O₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGGTase-I
      Primary Target IC<sub>50</sub>500 nM in blocking the geranyl-geranylation of Rap1A
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      345885-250UG 04055977214529

      Documentation

      GGTI-2147 - CAS 191102-87-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      GGTI-2147 - CAS 191102-87-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      345885

      References

      Reference overview
      Bernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
      Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      Synonyms4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
      DescriptionMethyl ester derivative of GGTI-2133 (Cat. No. 345884). A potent and selective non-thiol inhibitor of geranylgeranyltransferase I (GGTase I) over farnesyltransferase (FTase) in whole cells. Blocks the geranylgeranylation of Rap1A with an IC50 value greater than 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 <30 µM for H-Ras).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number191102-87-1
      Chemical formulaC₂₈H₃₀N₄O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBernot, D., et al. 2003. J. Cardiovasc. Pharmacol. 41, 316.
      Vasudevan, A., et al. 1999. J. Med. Chem. 42, 1333.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Farnesyltransferase (FTase), Geranylgeranyltransferase (GGTase), & Methyltransferase Inhibitors