345878 Sigma-AldrichGGTI-286 - CAS 171744-11-9 - Calbiochem
GGTI-286, CAS 171744-11-9, is a cell-permeable, potent, and selective inhibitor of GGTase I. It is about 25-fold more potent (IC50 = 2 µM) than FTI-277 in inhibiting the processing of Rap1A protein.
More>> GGTI-286, CAS 171744-11-9, is a cell-permeable, potent, and selective inhibitor of GGTase I. It is about 25-fold more potent (IC50 = 2 µM) than FTI-277 in inhibiting the processing of Rap1A protein. Less<<GGTI-286 - CAS 171744-11-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 171744-11-9 | C₂₃H₃₁N₃O₃S |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 345878-250UG |
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Plastic ampoule | 250 μg |
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| Description | |
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| Overview | A potent, cell-permeable, and selective inhibitor of GGTase I. This methyl ester derivative of GGTI-287 (Cat. No. 345880) is about 25-fold more potent (IC50 = 2 µM vs. 50 µM) than FTI-277 (Cat. No. 344555) in inhibiting the processing of the geranylgeranylated protein Rap1A. Selectively antagonizes oncogenic K-Ras4B (IC50 = 2 µM). GGTI-286 has also been shown to have a significant antiproliferative effect in human malignant glioma cells. |
| Catalogue Number | 345878 |
| Brand Family | Calbiochem® |
| Synonyms | N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(L)-leucine methyl ester, TFA |
| Product Information | |
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| CAS number | 171744-11-9 |
| ATP Competitive | N |
| Form | Glassy solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₂₃H₃₁N₃O₃S |
| Chemical formula | C₂₃H₃₁N₃O₃S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | Geranylgeranyltransferase (GGTase) |
| Primary Target IC<sub>50</sub> | 2 µM against GGTase |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 345878-250UG | 04055977214505 |
Documentation
GGTI-286 - CAS 171744-11-9 - Calbiochem SDS
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GGTI-286 - CAS 171744-11-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 345878 |
References
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| Bredel, M., et al. 1998. Neurosurgery 43, 124. Qian, Y., et al. 1998. Bioorg. Med. Chem. 6, 293. Lerner, E.C., et al. 1997. Oncogene 15, 1283. Lerner, E.C., et al. 1995. J. Biol. Chem. 270, 26770. |
Citations
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