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361526 GSK-3β, Rabbit Skeletal Muscle, Recombinant, E. coli

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361526
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361526-5KU
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      Description
      OverviewRecombinant, rabbit glycogen synthase kinase 3β expressed in E. coli. Dual specificity kinase. One of several protein kinases that phosphorylates glycogen synthase. Other substrates include p90rsk, Tau, c-Jun, and CREB. Plays a key role in Wnt and insulin signaling.
      Note: 1 KU = 1000 units.
      Catalogue Number361526
      Brand Family Calbiochem®
      SynonymsGSK 3β-Isozyme, Rabbit Skeletal Muscle, Recombinant, E. coli
      References
      ReferencesDajani, R., et al. 2001. Cell 105, 721.
      Wang, Q.M., et al. 1995. Biochem. Biophys. Res. Commun. 208, 796.
      Fiol, C.J., et al. 1994. J. Biol. Chem. 269, 32187.
      Wang, Q.M., et al. 1994. J. Biol. Chem. 269, 14566.
      Wang, Q.M., et al. 1994. Biochemistry 33, 143.
      deGroot, R.P., et al. 1993. Oncogene 8, 841.
      Ishiguro, K., et al. 1993. FEBS Lett. 325, 167.
      Product Information
      Activity≥250,000 units/ml
      Unit of DefinitionOne unit is defined as the amount of GSK-3 required to catalyze the transfer of 1 pmol phosphate to CREB phosphopeptide KRREILSRRPS(P)YRP (200 µM), in 1 min at 30°C in a reaction volume of 25 µl.
      FormLiquid
      FormulationIn 50 mM NaCl, 30 mM Tris-HCl, 5 mM DTT, 1 mM EDTA, 50% glycerol, 0.03% BRIJ®-35 Detergent, pH 7.5
      Quality LevelMQ100
      Applications
      ApplicationGSK-3β, Rabbit Skeletal MuscleHis-Tag®, Human, Recombinant, E. coli, is a dual specificity kinase that plays important roles in insulin- and Wnt-mediated signaling. It is inactivated by phosphorylation at Ser9.
      Physicochemical Information
      ContaminantsDNase: <10% conversion of RFI DNA to RFII and linear forms. Phosphatases and Proteases: none detected. RNases: <10% RNA degradation.
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw aliquot and freeze (-20°C).
      Global Trade Item Number
      Catalog Number GTIN
      361526-5KU 04055977192933