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356310 Glyburide - CAS 10238-21-8 - Calbiochem

A sulfonylurea that selectively blocks ATP-sensitive K+ channels.

Glyburide - CAS 10238-21-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Glybenclamide

Primary Target: ATP-sensitive K+ channels
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356310
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
10238-21-8C₂₃H₂₈ClN₃O₅S

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      Description
      OverviewA sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide.
      Catalogue Number356310
      Brand Family Calbiochem®
      SynonymsGlybenclamide
      References
      ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
      Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
      Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
      Jacobs, D.R., et al. 1989. Diabetes 38, 205.
      Product Information
      CAS number10238-21-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₂₈ClN₃O₅S
      Chemical formulaC₂₃H₂₈ClN₃O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATP-sensitive K+ channels
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYS4725200
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      356310-1GM 04055977192711

      Documentation

      Glyburide - CAS 10238-21-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Glyburide - CAS 10238-21-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      356310

      References

      Reference overview
      Holzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
      Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
      Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
      Jacobs, D.R., et al. 1989. Diabetes 38, 205.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-May-2008 RFH
      SynonymsGlybenclamide
      DescriptionAntidiabetic sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. High-affinity binding sites are widely distributed and have been identified in the cardiovascular system, the central nervous system, and pancreatic β-cells. In cultured cells, glyburide enhances insulin action and stimulates the synthesis of glucose transporters. Displays large potency difference in action on pancreatic tissue (IC50 in nM range) and vascular tissue (IC50 in µM range).
      FormWhite solid
      CAS number10238-21-8
      RTECSYS4725200
      Chemical formulaC₂₃H₂₈ClN₃O₅S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml) or Ethanol (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 4478
      ReferencesHolzmann, S., et al. 1992. Eur. J. Pharmacol. 215, 1.
      Rabuazzo, A.M., et al. 1992. Endocrinology 131, 1815.
      Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther. 256, 358.
      Jacobs, D.R., et al. 1989. Diabetes 38, 205.