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371955 H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl

Primary Target: MLCK
371955
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
108930-17-2C₁₄H₁₇N₃O₂S · 2HCl

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371955-1MG
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      Description
      OverviewA broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor. Inhibits protein kinase A (Ki = 3.0 µM), myosin light chain kinase (Ki = 97 µM), protein kinase C (Ki = 6.0 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
      Catalogue Number371955
      Brand Family Calbiochem®
      Synonyms1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl
      References
      ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
      Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
      Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
      Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
      Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
      Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
      Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.
      Product Information
      CAS number108930-17-2
      ATP CompetitiveY
      FormLight yellow lyophilized solid
      Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
      Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMLCK
      Primary Target K<sub>i</sub>3.0 µM, 97 µM, 6.0 µM, 5.8 µM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      371955-1MG 04055977213485

      Documentation

      H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      371955

      References

      Reference overview
      Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
      Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
      Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
      Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
      Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
      Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
      Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

      Brochure

      Title
      PKC Pathway Poster PDF ( 676 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-January-2010 RFH
      Synonyms1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl
      DescriptionA broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 µM), protein kinase A (Ki = 3.0 µM), protein kinase C (Ki = 6 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
      FormLight yellow lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number108930-17-2
      Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (20 mg/ml). Further dilute with aqueous buffers just prior to use.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
      Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
      Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
      Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
      Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
      Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
      Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

      Related Products & Applications

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors