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384620 Honokiol - CAS 35354-74-6 - Calbiochem

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

Honokiol - CAS 35354-74-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV

Primary Target: Anti-angiogenic, anti-tumor and anxiolytic properties
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384620
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
35354-74-6C₁₈H₁₈O₂

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384620-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewA biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.
      Catalogue Number384620
      Brand Family Calbiochem®
      Synonyms5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
      References
      ReferencesBai, X., et al. 2003. J. Biol. Chem. 278, 35501.
      Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
      Son, H.J., et al. 2000. Planta Med. 66, 469.
      Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.
      Product Information
      CAS number35354-74-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₁₈O₂
      Chemical formulaC₁₈H₁₈O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAnti-angiogenic, anti-tumor and anxiolytic properties
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      384620-10MG 04055977190267

      Documentation

      Honokiol - CAS 35354-74-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Honokiol - CAS 35354-74-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      384620

      References

      Reference overview
      Bai, X., et al. 2003. J. Biol. Chem. 278, 35501.
      Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
      Son, H.J., et al. 2000. Planta Med. 66, 469.
      Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-May-2008 RFH
      Synonyms5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
      DescriptionThe active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number35354-74-6
      Chemical formulaC₁₈H₁₈O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 4742
      ReferencesBai, X., et al. 2003. J. Biol. Chem. 278, 35501.
      Yang, S.E., et al. 2002. Biochem. Pharmacol. 63, 1641.
      Son, H.J., et al. 2000. Planta Med. 66, 469.
      Maruyama, Y., et al. 1998. J. Nat. Prod. 61, 135.