217721 Sigma-AldrichInSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem
The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one
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Overview
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Key Specifications Table
| Empirical Formula |
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| C₁₈H₁₃N₃OS₂ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 217721-2MG |
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Glass bottle | 2 mg |
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| Description | |
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| Overview | A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available. |
| Catalogue Number | 217721 |
| Brand Family | Calbiochem® |
| Synonyms | 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one |
| References | |
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| References | Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |
| Product Information | |
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| Form | Liquid |
| Formulation | A 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO. |
| Hill Formula | C₁₈H₁₃N₃OS₂ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Cdk1/B1 and Cdk1/A |
| Primary Target K<sub>i</sub> | 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, |
| Secondary target | Cdk2/E, PKCδ, and SGK |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalog Number | GTIN |
| 217721-2MG | 04055977202410 |
Documentation
InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem SDS
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InSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 217721 |
References
| Reference overview |
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| Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |
| Data Sheet | ||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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