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475821 InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
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475821
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₄₉H₇₄N₁₀O₁₂

Pricing & Availability

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475821-250UG
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      		 Plastic Bag(s) 250 μg
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      Description
      Catalogue Number475821
      Brand Family Calbiochem®
      References
      ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
      Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
      Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
      Cohen, P., et al. 1989. FEBS Lett. 250, 596.
      Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.
      Product Information
      ATP CompetitiveN
      DeclarationNot available for sale outside of the United States.
      FormLiquid
      FormulationA 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475815) in DMSO.
      Hill FormulaC₄₉H₇₄N₁₀O₁₂
      Chemical formulaC₄₉H₇₄N₁₀O₁₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetprotein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
      Primary Target IC<sub>50</sub>1.7 nM, 40 pM, against protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A), respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      End use certificateY
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      475821-250UG 04055977184853

      Documentation

      InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem Certificates of Analysis

      TitleLot Number
      475821

      References

      Reference overview
      Craig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
      Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
      Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
      Cohen, P., et al. 1989. FEBS Lett. 250, 596.
      Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.

      Brochure

      Title
      In Solution! Product Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 RFH
      DescriptionCyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing contaminating phosphatase activities in protein kinase assays.
      FormLiquid
      FormulationA 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475815) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₉H₇₄N₁₀O₁₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Highly Toxic
      ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
      Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
      Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
      Cohen, P., et al. 1989. FEBS Lett. 250, 596.
      Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.