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566661 InSolution™ Smoothened Agonist, SAG - Calbiochem

InSolution™ Smoothened Agonist, SAG, is a 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SAG1.3 in Solution

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566661
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₈H₂₈ClN₃OS • 2HCl • H₂O

Pricing & Availability

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566661-500UG
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      		 Plastic ampoule 500 μg
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      Description
      Catalogue Number566661
      Brand Family Calbiochem®
      SynonymsSAG1.3 in Solution
      References
      ReferencesMeloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
      Chen, W., et al. 2004. Science 306, 2257.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Product Information
      FormLiquid
      FormulationA 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.
      Hill FormulaC₂₈H₂₈ClN₃OS • 2HCl • H₂O
      Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      566661-500UG 04055977191585

      Documentation

      InSolution™ Smoothened Agonist, SAG - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Smoothened Agonist, SAG - Calbiochem Certificates of Analysis

      TitleLot Number
      566661

      References

      Reference overview
      Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
      Chen, W., et al. 2004. Science 306, 2257.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-February-2009 JSW
      SynonymsSAG1.3 in Solution
      DescriptionA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
      FormLiquid
      FormulationA 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesMeloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
      Chen, W., et al. 2004. Science 306, 2257.
      Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
      Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.