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435800 Licochalcone-A, Synthetic - CAS 58749-22-7 - Calbiochem

Licochalcone-A, Synthetic, CAS 58749-22-7, is an estrogenic flavonoid with anti-tumor & antiparasitic properties. Reduces Bcl-2 expression and induces apoptosis in several human cancer cell lines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one

Primary Target: Anti-tumor and antiparasitic properties
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435800
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
58749-22-7C₂₁H₂₂O₄

Pricing & Availability

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435800-10MG
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      435800-50MG
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          Description
          OverviewAn estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
          Catalogue Number435800
          Brand Family Calbiochem®
          Synonyms(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
          References
          ReferencesRafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
          Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
          Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
          Park, E.J., et al. 1998. Planta Med. 64, 464.
          Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
          Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.
          Product Information
          CAS number58749-22-7
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₂₁H₂₂O₄
          Chemical formulaC₂₁H₂₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationLicochalcone-A, Synthetic, CAS 58749-22-7, is an estrogenic flavonoid with anti-tumor & antiparasitic properties. Reduces Bcl-2 expression and induces apoptosis in several human cancer cell lines.
          Biological Information
          Primary TargetAnti-tumor and antiparasitic properties
          Purity≥96% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          435800-10MG 04055977210309
          435800-50MG 04055977210316

          Documentation

          Licochalcone-A, Synthetic - CAS 58749-22-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Licochalcone-A, Synthetic - CAS 58749-22-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          435800

          References

          Reference overview
          Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
          Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
          Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
          Park, E.J., et al. 1998. Planta Med. 64, 464.
          Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
          Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-August-2008 RFH
          Synonyms(E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
          DescriptionAn estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number58749-22-7
          Chemical formulaC₂₁H₂₂O₄
          Structure formulaStructure formula
          Purity≥96% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol. Further dilute 1:10 with aqueous buffer or medium just prior to use.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          ReferencesRafi, M.M., et al. 2000. Anticancer Res. 20, 2653.
          Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.
          Haraguchi, H., et al. 1998. Phytochemistry 48, 125.
          Park, E.J., et al. 1998. Planta Med. 64, 464.
          Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.
          Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.