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FCMAB314F Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B

Detect CNPase using this Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B validated for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: CNP, CNPase, CNP1, EC 3.1.4.37 UniProt Number: P09543
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FCMAB314F
100 tests  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB314F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark Anti-CNPase-FITC Antibody, clone 11-5B
      Alternate Names
      • 2'3'-Cyclic Nucleotide 3'-Phosphohydrolase
      Background InformationCNPase (2', 3'-cyclic nucleotide 3'-phosphodiesterase [or -phosphohydrolase], EC 3.1.4.37) is present in very high levels in brain and peripheral nerve. This enzyme is found almost exclusively in oligo-dendrocytes and Schwann cells, the cells that form myelin in the central and peripheral nervous system, respectively.
      Immunohistochemical localization of CNPase has shown the enzyme to be restricted to oligodendrocytes and Schwann cells. The enzyme appears to be distributed in single and double loose wraps of myelin and not in compact myelin as earlier thought by most investigators. CNPase is located on the inner and outer loops of myelin, paranodally and near the inner surface of the oligodendrocyte membrane. In plaque regions of multiple sclerosis patients, the enzyme is reduced, and when CNS myelin is decreased, CNPase is one of the earlier proteins to be lost from the myelin. In addition, an enzyme that is probably identical to brain CNPase is located in the outer rod segments within the visual system, and this protein is also recognized by the monoclonal antibody 11-5B. In mixed human gliomas, the enzyme levels are reduced, although about 5% of the oligodendrocytes occasionally show normal positive staining.
      References
      Product Information
      FormatFITC
      Control
      • U251 Cells
      PresentationPurified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationDetect CNPase using this Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B validated for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenPurified human brain CNPase protein.
      Clone11-5B
      HostMouse
      SpecificityAntibody recognizes Human CNPase protein.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CNP
      • CNPase
      • CNP1
      • EC 3.1.4.37
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummarySIZE: 421 amino acids; 47579 Da

      SUBCELLULAR LOCATION: Membrane. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

      SIMILARITY: SwissProt: P09543 ## Belongs to the cyclic nucleotide phosphodiesterase family.
      Molecular Weight48kDa Calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using U251 Cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      FCMAB314F 04053252754579

      Documentation

      Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark Anti-CNPase-FITC Antibody, clone 11-5B Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CNPase-FITC, clone 11-5B - 2204987 2204987
      Milli-Mark#174; Anti-CNPase-FITC, clone 11-5B - 2153058 2153058
      Milli-Mark#174; Anti-CNPase-FITC, clone 11-5B - 2047696 2047696
      Milli-Mark#174; Anti-CNPase-FITC, clone 11-5B - NRG1919865 NRG1919865
      Milli-Mark™ Anti-CNPase-FITC, -2716777 2716777
      Milli-Mark™ Anti-CNPase-FITC, -2820238 2820238
      Milli-Mark™ Anti-CNPase-FITC, clone 11-5B - 3998961 3998961
      Milli-Mark™ Anti-CNPase-FITC, clone 11-5B Conjugate 2937354
      Milli-Mark™ Anti-CNPase-FITC, clone 11-5B Conjugate 2939556
      Milli-Mark™ Anti-CNPase-FITC,clone 11-5B - 3150398 3150398
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies