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483125 NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem

Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl

Primary Target: eNOS
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483125
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
51298-62-5C₇H₁₅N₅O₄ . HCl

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483125-100MG
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      Description
      OverviewCell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
      Catalogue Number483125
      Brand Family Calbiochem®
      SynonymsNω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
      References
      ReferencesBaylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
      Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
      Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.
      Product Information
      CAS number51298-62-5
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₇H₁₅N₅O₄ . HCl
      Chemical formulaC₇H₁₅N₅O₄ . HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargeteNOS
      Primary Target IC<sub>50</sub>500 nM against eNOS
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      483125-100MG 04055977200652

      Documentation

      NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      483125

      References

      Reference overview
      Baylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
      Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
      Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-November-2010 RFH
      SynonymsNω-NO₂-L-Arg-OMe, NG-NO₂-L-Arg-OMe, L-NAME, HCl
      DescriptionMore soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number51298-62-5
      Chemical formulaC₇H₁₅N₅O₄ . HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesBaylis, C., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1135.
      Dawson, V.L., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 6368.
      Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
      Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
      Moore, P.K., et al. 1990. Br. J. Pharmacol. 99, 408.