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487957 Sigma-AldrichNOC-18 - CAS 146724-94-9 - Calbiochem

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

NOC-18 - CAS 146724-94-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate

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Overview

Replacement Information

Key Specifications Table

CAS #	Empirical Formula
146724-94-9	C₄H₁₃N₅O₂

Pricing & Availability

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Description
Overview	A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺ in vitro. Half-life (t_½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).
Catalogue Number	487957
Brand Family	Calbiochem®
Synonyms	DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate

References
References	Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306. Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103. Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519. Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287. Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

Product Information
CAS number	146724-94-9
ATP Competitive	N
Form	White solid
Hill Formula	C₄H₁₃N₅O₂
Chemical formula	C₄H₁₃N₅O₂
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	A nitric oxide (NO) donor
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
487957-10MG	04055977200430

Documentation

NOC-18 - CAS 146724-94-9 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

NOC-18 - CAS 146724-94-9 - Calbiochem Certificates of Analysis

Title	Lot Number
487957	Enter Lot Number

References

Reference overview
Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306. Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103. Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519. Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287. Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-July-2019 JSW
Synonyms	DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
Description	A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t_½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺ in vitro.
Form	White solid
CAS number	146724-94-9
Chemical formula	C₄H₁₃N₅O₂
Structure formula
Purity	≥90% by HPLC
Solubility	0.1N NaOH (10 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.
Toxicity	Irritant
References	Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306. Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103. Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519. Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287. Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

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