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GF343 PDGF-AA,
Human Recombinant Animal Free

PDGF-AA,
Human Recombinant Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P04085
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GF343
10µg  
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      Overview

      Replacement Information

      Key Specifications Table

      SourcePurity
      Protein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.      		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      Description
      Catalogue NumberGF343
      DescriptionPDGF-AA,
      Human Recombinant Animal Free
      Alternate Names
      • PDGFA
      • PDGF-1
      • PDGF-A
      • PDGF1
      Background InformationPDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR- α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGFBB and PDGF-AB.
      Recombinant human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).
      References
      Product Information
      PresentationProduct is presented in 10mM Acetic Acid and is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      SourceProtein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceDetermined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
      Packaging Information
      Material Size10µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      GF343 04053252979026

      Documentation

      PDGF-AA,
      Human Recombinant Animal Free SDS

      Title

      Safety Data Sheet (SDS) 

      PDGF-AA,
      Human Recombinant Animal Free Certificates of Analysis

      TitleLot Number
      PDGF-AA, Human Recombinant Animal Free - Q2447016 Q2447016
      PDGF-AA, Human Recombinant Animal Free - 3229429 3229429
      PDGF-AA, Human Recombinant Animal Free - 3511587 3511587
      PDGF-AA, Human Recombinant Animal Free - 3689441 3689441
      PDGF-AA, Human Recombinant Animal Free - 3911798 3911798
      PDGF-AA, Human Recombinant Animal Free - 4064291 4064291
      PDGF-AA, Human Recombinant Animal Free Recombinant Protein 2853641
      PDGF-AA,-2566794 2566794

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