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14-604 PI3 Kinase (p110δ/p85α) Protein, active, 10 µg

Active complex of N-terminal His6-tagged recombinant, full-length, human p110δ & untagged, recombinant, full length, human p85α. For use in Kinase Assays.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-604
10 µg  Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-604M when ordering the 250μg size.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-604
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 Kinase (p110δ/p85α) Protein, active, 10 µg
      OverviewComplex of N-terminal His6-tagged recombinant, full-length, human p110δ and untagged, recombinant, full length, human p85α
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive complex of N-terminal His6-tagged recombinant, full-length, human p110δ & untagged, recombinant, full length, human p85α. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceCoexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryPhosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. See MIM 602838. The class I PI3Ks display a broad phosphoinositide lipid substrate specificity and include p110-alpha (MIM 171834), p110-beta (MIM 602925), and p110-gamma (MIM 601232). p110-alpha and p110-beta interact with SH2/SH3-domain-containing p85 adaptor proteins (see MIM 171833) and with GTP-bound Ras.[supplied by OMIM]
      Gene Symbol
      • PIK3CD
      • p110d
      • PI3K
      • p110D
      • p110delta
      Protein TargetPI3Kδ/p85α
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummarySIZE: 1044 amino acids; 119479 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Interacts with ERAS (By similarity).
      TISSUE SPECIFICITY: Expressed predominantly in leukocytes.
      PTM: Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.
      SIMILARITY: SwissProt: O00329 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain.
      Molecular WeightP110δ (121.6kDa) & p85α (83.7kDa)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by the PIProfiler™
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-604M when ordering the 250μg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-604 04053252268816

      Documentation

      PI3 Kinase (p110δ/p85α) Protein, active, 10 µg SDS

      Title

      Safety Data Sheet (SDS) 

      PI3 Kinase (p110δ/p85α) Protein, active, 10 µg Certificates of Analysis

      TitleLot Number
      PI3 Kinase (p110#948;/p85#945;) - 1838059-E 1838059-E
      PI3 Kinase (p110#948;/p85#945;) - 1838059-F 1838059-F
      PI3 Kinase (p110#948;/p85#945;) - 1894125-G 1894125-G
      PI3 Kinase (p110#948;/p85#945;) - 1894125-H 1894125-H
      PI3 Kinase (p110#948;/p85#945;) - 1894125-I 1894125-I
      PI3 Kinase (p110#948;/p85#945;) - 1894125-J 1894125-J
      PI3 Kinase (p110#948;/p85#945;) - 1947945-E 1947945-E
      PI3 Kinase (p110#948;/p85#945;) - 1947945-G 1947945-G
      PI3 Kinase (p110#948;/p85#945;) - 1947945-H 1947945-H
      PI3 Kinase (p110δ/p85α) - 1894125-K 1894125-K

      Technical Info

      Title
      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

      Data Sheet

      Title
      PI 3-Kinase HTRF Assay

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-604M PI3 Kinase (p110δ/p85α) Protein, active, 250 µg Show Pricing & Availability

      Product Families

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      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases