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14-602 PI3 Kinase (p110α/p85α) Protein, active, 20 µg

Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-602
20 µg  Also available in 250μg size as catalog # 14-602M - Call for pricing and availability.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-602
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 Kinase (p110α/p85α) Protein, active, 20 µg
      OverviewComplex of N-terminal His6-tagged recombinant full-length human p110α and untagged, recombinant, full length, human p85α
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceCoexpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryPhosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
      Gene Symbol
      • PIK3CA
      • PI3K
      • MGC142161
      • p110-alpha
      • MGC142163
      Protein TargetPI3Kα/p85α
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
      SIZE: 1068 amino acids; 124284 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
      DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
      SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
      Molecular Weightp110α (125.3kDa) & p85α (83.7kDa)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by PIProfiler
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size20 µg
      Material PackageAlso available in 250μg size as catalog # 14-602M - Call for pricing and availability.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-602 04053252405501

      Documentation

      PI3 Kinase (p110α/p85α) Protein, active, 20 µg SDS

      Title

      Safety Data Sheet (SDS) 

      PI3 Kinase (p110α/p85α) Protein, active, 20 µg Certificates of Analysis

      TitleLot Number
      PI3 Kinase (p110#945;/p85#945;), active - 1794230-F 1794230-F
      PI3 Kinase (p110#945;/p85#945;), active - 1794230-M 1794230-M
      PI3 Kinase (p110#945;/p85#945;), active - 1794230-N 1794230-N
      PI3 Kinase (p110#945;/p85#945;), active - 1794230-O 1794230-O
      PI3 Kinase (p110#945;/p85#945;), active - 1945160-A 1945160-A
      PI3 Kinase (p110#945;/p85#945;), active - 2052238-A 2052238-A
      PI3 Kinase (p110#945;/p85#945;), active - 2052238-C 2052238-C
      PI3 Kinase (p110#945;/p85#945;), active - 2052238-D 2052238-D
      PI3 Kinase (p110#945;/p85#945;), active - 2150294-A 2150294-A
      PI3 Kinase (p110α/p85α), active - 2052238-E 2052238-E

      Technical Info

      Title
      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

      Data Sheet

      Title
      PI 3-Kinase HTRF Assay

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-602M PI3 Kinase (p110α/p85α) Protein, active, 250 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases