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530050 PRIMA-1 - CAS 5608-24-2 - Calbiochem

A cell-permeable quinuclidinone analog with antitumor properties.

PRIMA-1 - CAS 5608-24-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis

Primary Target: Restores biochemical and biological function to mutant p53
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530050
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
5608-24-2C₉H₁₅NO₃

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530050-10MG
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      Description
      OverviewA cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.
      Catalogue Number530050
      Brand Family Calbiochem®
      Synonyms2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
      References
      ReferencesBykov, V.J., et al. 2002. Nat. Med. 8, 282.
      Product Information
      CAS number5608-24-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₉H₁₅NO₃
      Chemical formulaC₉H₁₅NO₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRestores biochemical and biological function to mutant p53
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      530050-10MG 04055977269345

      Documentation

      PRIMA-1 - CAS 5608-24-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PRIMA-1 - CAS 5608-24-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      530050

      References

      Reference overview
      Bykov, V.J., et al. 2002. Nat. Med. 8, 282.

      Brochure

      Title
      Interactive Pathway Calendar
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
      DescriptionA cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5608-24-2
      Chemical formulaC₉H₁₅NO₃
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityH₂O (2 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBykov, V.J., et al. 2002. Nat. Med. 8, 282.