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537983 Pantothenate Kinase Inhibitor - Calbiochem

Cell-permeable, potent and reversible PanK inhibitor. Blocks de novo CoA biosynthesis (IC₅₀ = 0.9 µM in C3A cells).

Pantothenate Kinase Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor

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537983
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      Description
      OverviewA cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [3H]pantothenate incorporation into coenzyme A (apparent IC50 = 900 nM in C3A cells) with negligible off-target toxicity (IC50 > 56 µM in Hep-G2 cells).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number537983
      Brand Family Calbiochem®
      Synonyms3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
      DescriptionPantothenate Kinase Inhibitor
      References
      ReferencesSharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
      Product Information
      FormOrange solid
      Hill FormulaC₂₁H₂₁N₅O
      Chemical formulaC₂₁H₂₁N₅O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetpantothenate kinase
      Primary Target IC<sub>50</sub>70, 92 and 25 nM for PanK1&beta
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5.37983.0001 04054839133381

      Documentation

      Pantothenate Kinase Inhibitor - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Sharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-September-2016 JSW
      Synonyms3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
      DescriptionA cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [3H]pantothenate incorporation into coenzyme A (apparent IC50 = 900 nM in C3A cells) with negligible off-target toxicity (IC50 > 56 µM in Hep-G2 cells).
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₂₁N₅O
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.