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516483 Pepstatin A, Penetratin - Calbiochem

A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays.

Pepstatin A, Penetratin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈

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516483
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₃₈H₂₂₉N₃₉O₂₈S

Pricing & Availability

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516483-1MG
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      Description
      OverviewA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
      Catalogue Number516483
      Brand Family Calbiochem®
      SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
      References
      ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
      Product Information
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      516483-1MG 04055977198843

      Documentation

      Pepstatin A, Penetratin - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pepstatin A, Penetratin - Calbiochem Certificates of Analysis

      TitleLot Number
      516483

      References

      Reference overview
      Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2009 RFH
      SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
      DescriptionA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
      Purity≥97% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.