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416154 Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem

Pre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

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416154
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
548-19-6C₃₂H₂₂O₁₀

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416154-10MG
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      		 Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 µM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
      Catalogue Number416154
      Brand Family Calbiochem®
      Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
      References
      ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
      O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
      Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
      Product Information
      CAS number548-19-6
      FormYellow solid
      Hill FormulaC₃₂H₂₂O₁₀
      Chemical formulaC₃₂H₂₂O₁₀
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      416154-10MG 04055977187786

      Documentation

      Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      416154

      References

      Reference overview
      Kim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
      O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
      Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-September-2012 JSW
      Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
      DescriptionA naturally isolated Ginkgo biloba biflavanoid that acts as a cell-permeable, reversible inhibitor against spliceosome-mediated pre-mRNA splicing (IC50 and ICmax = 30 and 50 µM, respectively, in splicing assays using HeLa nuclear extract) by preventing the prespliceosome A complex from recruiting the U4/U5/U6 tri-snRNP (stable nuclear RNA and its associated proteins) to form B complex. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number548-19-6
      Chemical formulaC₃₂H₂₂O₁₀
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
      O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
      Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.