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567735 Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SPC, lyso-Sphingomyelin

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567735
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1670-26-4C₂₃H₄₉N₂O₅P

Pricing & Availability

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567735-10MG
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      Description
      OverviewSPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
      Catalogue Number567735
      Brand Family Calbiochem®
      SynonymsSPC, lyso-Sphingomyelin
      References
      ReferencesBerger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
      Dettbarn, C., et al. 1995. Brain Res. 669, 79.
      Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
      Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.
      Product Information
      CAS number1670-26-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₃H₄₉N₂O₅P
      Chemical formulaC₂₃H₄₉N₂O₅P
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA potent mitogen
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      567735-10MG 04055977190908

      Documentation

      Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Sphingosylphosphoryl-choline - CAS 1670-26-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      567735

      References

      Reference overview
      Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
      Dettbarn, C., et al. 1995. Brain Res. 669, 79.
      Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
      Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.

      Brochure

      Title
      Bioactive Lipids Technical Bulletin
      MAPK Pathway Poster ( 750 KB )
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      SynonymsSPC, lyso-Sphingomyelin
      DescriptionSPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss 3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
      FormWhite solid
      CAS number1670-26-4
      Chemical formulaC₂₃H₄₉N₂O₅P
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityChloroform:Methanol (2:1) (1 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesBerger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
      Dettbarn, C., et al. 1995. Brain Res. 669, 79.
      Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
      Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.