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14-646M TCPTP Protein, 250 µg

Un-tagged, recombinant, human TCPTP, amino acids 1-341. For use in Phosphatase Assays.

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14-646M
250 µg  Also available in 10 μg size (cat#14-646) and in bulk (cat#14-646-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-646M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionTCPTP Protein, 250 µg
      OverviewUn-tagged, recombinant, human TCPTP, amino acids 1-341.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationUn-tagged, recombinant, human TCPTP, amino acids 1-341. For use in Phosphatase Assays.
      Key Applications
      • Phosphatase Assay
      Biological Information
      SourceHuman TCPTP, expressed in E. coli cells.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.
      Gene Symbol
      • PTPN2
      • TCELLPTP
      • TCPTP
      • TC-PTP
      • PTPT
      Protein TargetTCPTP
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilyTyr phosphatase
      UniProt Number
      UniProt SummarySIZE: 415 amino acids; 48528 Da
      SUBUNIT: Interacts with FAM82C/PTPIP51.
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: PTPA isoform is probably the major PTP expressed in human tissues. PTPB isoform was found in T-cells and in placenta.
      SIMILARITY: SwissProt: P17706 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
      Molecular Weight39.7kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by dephosphorylation of DiFMUP.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-646) and in bulk (cat#14-646-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      14-646M 04053252924545

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalog Number Description  
      14-646 TCPTP Protein, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Phosphatases
      Life Science Research > Proteins and Enzymes > Purified Phosphatases