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645900 Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PG490

Primary Target: Activate DEVD-cleaving caspases
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645900
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
38748-32-2C₂₀H₂₄O₆

Pricing & Availability

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645900-1MG
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      645900-5MG
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          Description
          OverviewA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
          Catalogue Number645900
          Brand Family Calbiochem®
          SynonymsPG490
          References
          ReferencesZhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
          Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
          Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
          Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
          Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
          Yang, Y., et al. 1998. Immunopharmacology 40, 139.
          Product Information
          CAS number38748-32-2
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₂₄O₆
          Chemical formulaC₂₀H₂₄O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetActivate DEVD-cleaving caspases
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYK7751000
          Safety Information
          R PhraseR: 20/21/22-40

          Harmful by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          645900-1MG 04055977262193
          645900-5MG 04055977262209

          Documentation

          Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          645900

          References

          Reference overview
          Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
          Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
          Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
          Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
          Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
          Yang, Y., et al. 1998. Immunopharmacology 40, 139.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-May-2009 RFH
          SynonymsPG490
          DescriptionA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number38748-32-2
          RTECSYK7751000
          Chemical formulaC₂₀H₂₄O₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          ReferencesZhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
          Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
          Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
          Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
          Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
          Yang, Y., et al. 1998. Immunopharmacology 40, 139.