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505989 Vigabatrin - CAS 68506-86-5 - Calbiochem

Vigabatrin - CAS 68506-86-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Amino-5-hexenoic acid, GABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril

Primary Target: GABA Transaminase
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505989
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
68506-86-5C₆H₁₁NO₂

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      Description
      OverviewA selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9 mM)
      Catalogue Number505989
      Brand Family Calbiochem®
      Synonyms4-Amino-5-hexenoic acid, GABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril
      References
      ReferencesAbbot, E.L., et al. 2006. Br. J. Pharmacol. 147, 298.
      Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap. 276, 977.
      Product Information
      CAS number68506-86-5
      FormWhite solid
      Hill FormulaC₆H₁₁NO₂
      Chemical formulaC₆H₁₁NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGABA Transaminase
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      5.05989.0001 04055977262612

      Documentation

      Vigabatrin - CAS 68506-86-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Abbot, E.L., et al. 2006. Br. J. Pharmacol. 147, 298.
      Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap. 276, 977.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2013 JSW
      Synonyms4-Amino-5-hexenoic acid, GABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril
      DescriptionA selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9 mM)
      FormWhite solid
      CAS number68506-86-5
      Chemical formulaC₆H₁₁NO₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAbbot, E.L., et al. 2006. Br. J. Pharmacol. 147, 298.
      Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap. 276, 977.