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508146 WAY-100635 Maleate - CAS 634908-75-1 - Calbiochem

Overview

Key Specifications Table

CAS #Empirical Formula
634908-75-1C₂₅H₃₄N₄O₂·C₄H₄O₄

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      Glass bottle 10 mg
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      Description
      OverviewA selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
      Catalogue Number508146
      Brand Family Calbiochem®
      Synonyms5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
      References
      ReferencesHunt, G. E. et al. 2011. Brain Res. Bull. 86, 65.
      Caamano, R. I. et al. 2010. J. Exp. Biol. 213, 1813.
      Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 357, 205.
      Forster, E. A. et al. 1995. Eur. J. Pharmacol. 281, 81.
      Product Information
      CAS number634908-75-1
      FormOff-white solid
      Hill FormulaC₂₅H₃₄N₄O₂·C₄H₄O₄
      Chemical formulaC₂₅H₃₄N₄O₂·C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Target5-HT1A
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalog Number GTIN
      5.08146.0001 04055977242843