urea/Tris buffer (0.02 M Tris, HCl, pH 7.5, 7 M urea, 5 mM EDTA, 15 mM 2-mercaptoethanol): 1 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
Native troponin I purified from human heart. Inhibitory subunit of troponin that binds to actin in the absence of Ca2+, thus inhibiting the ATPase activity of actomyosin. Presence of hcTnI in plasma has been used for early detection of myocardial infarction. Useful as a standard in immunoassay and as an immunogen for antisera production. Also useful as a tracer for iodination.
Warning
Toxicity: Standard Handling (A)
Physical form
Lyophilized from 10 mM HCl.
Preparation Note
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Falahati, A., et al. 1999. Am. Heart J. 137, 332. Mangano, D.T. 1994. Anesthesiology 81, 1317.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Troponin together with tropomyosin, regulate the binding of myosin to actin. Troponin is a trimeric protein composed of Troponin subunits I, C and T. Troponin C binds calcium ions, Troponin T binds to tropomyosin and troponin I binds to actin
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