Huntington’s Disease
Mouse anti-Huntingtin (Cat. No. MAB5374) immunohistochemistry. Brain sections containing the hippocampus from HD transgenic mouse (R6/2) (Davis et al., 1997) at the age of 12 weeks were stained with MAB5374. Note that the antibody specifically reacts with intranuclear mutant huntingtin aggregates and smaller neuropil aggregates outside the nucleus. For immunohistochemistry, MAB5374 was used at 1:400 dilution.
Mouse anti-Huntingtin (Cat. No. MAB5374) immunohistochemistry. Brain sections containing the hippocampus from HD transgenic mouse (R6/2) (Davis et al., 1997) at the age of 12 weeks were stained with MAB5374. Note that the antibody specifically reacts with intranuclear mutant huntingtin aggregates and smaller neuropil aggregates outside the nucleus. For immunohistochemistry, MAB5374 was used at 1:400 dilution.

Huntington’s Disease (HD) is a devastating, hereditary, degenerative brain disorder for which there is, at present, no effective treatment or cure. Huntington’s Disease slowly diminishes the affected individual’s ability to walk, think, talk, and reason. Eventually, the person with Huntington’s Disease becomes totally dependent upon others. Huntington’s Disease profoundly affects the lives of entire families – emotionally, socially and economically. An inherited, autosomal dominant neurodegenerative disorder, Huntington’s Disease affects approximately 1 in 15,000 people. The disease is caused by polyglutamine expansion in the N-terminal region of the disease protein, appropriately named huntingtin, which is pathogenic in neurons. Antibodies to aggregated huntingtin and its inclusions have been used as markers for the pathogenesis of Huntington’s Disease and to diagnose disease progression. New protein targets associated with huntingtin are now detectable using Millipore antibodies.