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129741 α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem

α-Amanitin, Amanita sp., CAS 23109-05-9, is a toxic bicyclic octapeptide isolated from mushrooms. A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: RNA polymerase 2
129741
  
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      23109-05-9C₃₉H₅₄N₁₀O₁₄S
      Description
      Overview

      This product has been discontinued.



      Toxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
      Catalogue Number129741
      Brand Family Calbiochem®
      References
      ReferencesBaumann, K., et al. 1994. Protein Sci. 3, 750.
      Scheurlen, C., et al. 1994. Gastroenterology 32, 399.
      Kastrop, P.M., et al. 1991. Mol. Reprod. Dev. 28, 249.
      Tamin, A., et al. 1991. Virology 182, 393.
      Weiland, T. 1983. Int. J. Pept. Protein Res. 22, 257.
      Product Information
      CAS number23109-05-9
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₃₉H₅₄N₁₀O₁₄S
      Chemical formulaC₃₉H₅₄N₁₀O₁₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetRNA polymerase 2
      Purity≥90% by absorbance
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSBD6195000
      Safety Information
      R PhraseR: 26/28-33

      Very toxic by inhalation and if swallowed.
      Danger of cumulative effects.
      S PhraseS: 36/37-28-45

      Wear suitable protective clothing and gloves.

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Store in plastic following reconstitution; material adheres to glass in solution. Stock solutions are stable for up 1 week at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      129741 0

      Documentation

      α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      α-Amanitin, Amanita sp. - CAS 23109-05-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      129741

      References

      Reference overview
      Baumann, K., et al. 1994. Protein Sci. 3, 750.
      Scheurlen, C., et al. 1994. Gastroenterology 32, 399.
      Kastrop, P.M., et al. 1991. Mol. Reprod. Dev. 28, 249.
      Tamin, A., et al. 1991. Virology 182, 393.
      Weiland, T. 1983. Int. J. Pept. Protein Res. 22, 257.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      DescriptionToxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
      FormWhite lyophilized solid
      CAS number23109-05-9
      RTECSBD6195000
      Chemical formulaC₃₉H₅₄N₁₀O₁₄S
      Structure formulaStructure formula
      Purity≥90% by absorbance
      SolubilityMeOH or H₂O (10 mg/ml). Reconstitute to a concentration ≥1 mM.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Store in plastic following reconstitution; material adheres to glass in solution. Stock solutions are stable for up 1 week at 4°C.
      Toxicity Highly Toxic
      Merck USA index14, 373
      ReferencesBaumann, K., et al. 1994. Protein Sci. 3, 750.
      Scheurlen, C., et al. 1994. Gastroenterology 32, 399.
      Kastrop, P.M., et al. 1991. Mol. Reprod. Dev. 28, 249.
      Tamin, A., et al. 1991. Virology 182, 393.
      Weiland, T. 1983. Int. J. Pept. Protein Res. 22, 257.