203729 Sigma-Aldrich(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem
(+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.
More>> (+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
Recommended Products
Overview
| Replacement Information |
|---|
Key Specifications Table
| CAS # | Empirical Formula |
|---|---|
| 20350-15-6 | C₁₆H₂₄O₄ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 203729-1MG |
|
Plastic ampoule | 1 mg |
|
— |
| Description | |
|---|---|
| Overview | Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583). |
| Catalogue Number | 203729 |
| Brand Family | Calbiochem® |
| Synonyms | 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one |
| Product Information | |
|---|---|
| CAS number | 20350-15-6 |
| ATP Competitive | N |
| Form | White crystalline solid |
| Hill Formula | C₁₆H₂₄O₄ |
| Chemical formula | C₁₆H₂₄O₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS | |
|---|---|
| RTECS | GY8410000 |
| Safety Information | |
|---|---|
| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 36 Wear suitable protective clothing. |
| Product Usage Statements |
|---|
| Packaging Information |
|---|
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalog Number | GTIN |
| 203729-1MG | 07790788048389 |
Documentation
(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem SDS
| Title |
|---|
(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 203729 |
References
| Reference overview |
|---|
| Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567. Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856. Mendez, A.J. 1995. J. Biol. Chem. 270, 5891. Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023. Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063. Ktistakis, N.Y., et al. 1992. Nature 356, 344. |
Citations
| Title | |
|---|---|
|
|
| Data Sheet | ||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|