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565789 γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem

This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine

Primary Target: γ-secretase
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565789
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
209984-56-5C₂₆H₂₃F₂N₃O₃

Pricing & Availability

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565789-1MG
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      565789-500UG
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          Description
          OverviewA cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p).
          Catalogue Number565789
          Brand Family Calbiochem®
          Synonyms(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
          References
          ReferencesDroy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
          van Es, J.H., et al. 2005. Nature 435, 959.
          Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
          Product Information
          CAS number209984-56-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₆H₂₃F₂N₃O₃
          Chemical formulaC₂₆H₂₃F₂N₃O₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetγ-secretase
          Primary Target IC<sub>50</sub>1.7 nM inhibiting Notch processing in SupT1 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalog Number GTIN
          565789-1MG 04055977191837
          565789-500UG 04055977191844

          Documentation

          γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          565789

          References

          Reference overview
          Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
          van Es, J.H., et al. 2005. Nature 435, 959.
          Milano, J., et al. 2004. Toxicol. Sci. 82, 341.

          Citations

          Title
        • Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-February-2012 RFH
          Synonyms(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
          DescriptionA cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number209984-56-5
          Chemical formulaC₂₆H₂₃F₂N₃O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDroy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
          van Es, J.H., et al. 2005. Nature 435, 959.
          Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
          Citation
        • Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
          		•