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441251 Sigma-Aldrichα₂-Macroglobulin, Human Plasma - Calbiochem

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

α₂-Macroglobulin, Human Plasma - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: α₂M, α₂MG

Primary Target: broad range protease

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Overview

Replacement Information

Pricing & Availability

Catalog Number	Availability	Packaging	Qty/Pack	Price	Quantity
441251-10MG	Retrieving availability... — Limited Availability Stocked Discontinued Limited Quantities Available Available Login to See Inventory Stocked Limited Availability Stocked Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Plastic ampoule	10 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites
441251-1MG	Retrieving availability... — Limited Availability Stocked Discontinued Limited Quantities Available Available Login to See Inventory Stocked Limited Availability Stocked Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Plastic ampoule	1 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α₂M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Catalogue Number	441251
Brand Family	Calbiochem®
Synonyms	α₂M, α₂MG

References
References	Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919. Boisset, N., et al. 1992. J. Struct. Biol. 108, 221. Barrett, A.J. 1980. Methods Enzymol. 80, 737.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	broad range protease
Purity	≥95% by SDS-PAGE
Source	Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalog Number	GTIN
441251-10MG	04055977206005
441251-1MG	04055977205992

Documentation

α₂-Macroglobulin, Human Plasma - Calbiochem SDS

Title
Safety Data Sheet (SDS)

α₂-Macroglobulin, Human Plasma - Calbiochem Certificates of Analysis

Title	Lot Number
441251	Enter Lot Number

References

Reference overview
Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919. Boisset, N., et al. 1992. J. Struct. Biol. 108, 221. Barrett, A.J. 1980. Methods Enzymol. 80, 737.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-August-2008 RFH
Synonyms	α₂M, α₂MG
Description	A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α₂M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.
Form	Lyophilized
Formulation	Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.
Source	Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Purity	≥95% by SDS-PAGE
Solubility	Aqueous buffers
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236. Lysiak, J.J., et al. 1995. J. Biol. Chem. 270, 21919. Boisset, N., et al. 1992. J. Struct. Biol. 108, 221. Barrett, A.J. 1980. Methods Enzymol. 80, 737.

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