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SCC607 3dGRO™ Human Lung Organoids (PDXO.149)

Cryopreserved Male Squamous Lung Organoids

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SCC607
≥ 1500 organoids/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC607
      Description3dGRO™ Human Lung Organoids (PDXO.149)
      Alternate Names
      • Lung PDO
      • Lung Tumor Organoid
      • Airway Organoid
      • Pulmonary Organoid
      Background InformationPatient-derived lung organoids (lung PDOs) are adult tissue derived in vitro cultured “mini-lungs” that accurately replicate the histological and functional aspects of in vivo lung tissue. Lung organoids have been shown to contain all 6 major lung epithelial cell types including AEC2s, AEC1s, basal cells, club cells, goblet cells and ciliated cells. These 3D organoid models have become attractive alternatives to traditional PDX and animal lung models to study pulmonary diseases including COPD, cystic fibrosis, SARS-CoV-2, viral infections, asthma, and lung cancer. The 3dGRO™ Human Lung Organoids are high quality cryopreserved cell lines derived from patient-derived xenografts, primary tumors or metastatic patient tissues from various regions of the human lung (acinar, papillary, solid, squamous, mucinous). These lung organoids are highly characterized and express lung airway markers including EPCAM, cytokeratin (CK5, CK7), acetyl-α-tubulin, surfactant proteins (SFTPB/SFTPC), TTF1, P63 and Muc5AC.

      Cell Line Characteristics
      • Sex: Male
      • Age: 62
      • Organ: Lung (PDX- Squamous)
      • Disease: Squamous Cell Carcinoma (Driver Mutations: PIK3CA AMP)
      References
      Product Information
      HS Code3002 59 00
      Quality LevelMQ100
      Applications
      ApplicationCryopreserved Male Squamous Lung Organoids
      Key Applications
      • Cell Culture
      • Stem Cell Culture
      Application Notes3dGRO™ is a trademark of KGaA, Darmstadt, Germany.
      3dGRO™ organoids were derived utilizing HUB Organoid Technology.
      The purchaser of this product shall agree to HUB’s terms of use, which shall be separately acknowledged and accepted by such purchaser, prior to transfer of this product to purchaser.
      Biological Information
      HostHuman
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1500 organoids.
      • Mycoplasma: Negative
      • Genotyped by STR analysis: Pass
      • Human species verified
      • Organoids are negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
      • Cell viability test: Pass
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions3dGRO™ human lung organoids should be stored in liquid nitrogen.
      Packaging Information
      Material Size≥ 1500 organoids/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      SCC607 04065267995151