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658460 AG 879 - CAS 148741-30-4 - Calbiochem

AG 879 - CAS 148741-30-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide

Primary Target: (NGF)-dependent p140c-trk tyrosine phosphorylation
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      148741-30-4C₁₈H₂₄N₂OS
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.
      Catalogue Number658460
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
      References
      ReferencesKonrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
      Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
      Product Information
      CAS number148741-30-4
      ATP CompetitiveN
      FormOrange-yellow solid
      Hill FormulaC₁₈H₂₄N₂OS
      Chemical formulaC₁₈H₂₄N₂OS
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target(NGF)-dependent p140c-trk tyrosine phosphorylation
      Primary Target IC<sub>50</sub>EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



      From Catalog:
      Solubility- removed acetic acid, MeOH
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      658460 0

      Documentation

      AG 879 - CAS 148741-30-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AG 879 - CAS 148741-30-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      658460

      References

      Reference overview
      Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
      Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 RFH
      Synonymsα-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
      DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140c-trk tyrosine phosphorylation (EC50 = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC50 = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.
      FormOrange-yellow solid
      CAS number148741-30-4
      Chemical formulaC₁₈H₂₄N₂OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityAcetic acid, DMSO (100 mg/ml), or methanol
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



      From Catalog:
      Solubility- removed acetic acid, MeOH
      Toxicity Standard Handling
      ReferencesKonrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
      Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
      Ohmichi, M., et al. 1993. Biochemistry 32, 4650.